ANALYSIS OF WALL SHEAR PARAMETERS OF PHYSIOLOGICAL PULSATILE FLOW THROUGH MILD AND SEVERE ARTERIAL STENOSIS AND CORRELATION TO ATHEROSCLEROSIS

Authors

  • Partha Goswami Mechanical Engineering Department, Jadavpur University, Kolkata, India
  • Dipak Kumar Mandal Mechanical Engineering Department, College of Engineering & Management, Kolaghat, Midnapur(E), India
  • Nirmal Kumar Manna Mechanical Engineering Department, Jadavpur University, Kolkata, India
  • Somnath Chakrabarty Mechanical Engineering Department, Indian Institute of Engineering, Science and Technology, Shibpur, Howrah, India

DOI:

https://doi.org/10.20319/Mijst.2016.23.4054

Keywords:

Atherosclerosis, Oscillatory Shear Index, Pulsatile, Relative Residence Time, Wall Shear Stress

Abstract

Numerical simulations of physiological pulsatile flow through mild and severe arterial stenosis are carried out to analyze wall shear stress parameters. The governing equations are solved by finite volume method. The study shows that the distribution patterns of time-averaged wall shear stress (TAWSS), oscillatory shear index (OSI) and relative residence time (RRT) are same forboth mild stenosis and severe stenosis. The magnitude of peak TAWSS and low TAWSS and extent of negative TAWSS of severe stenosis is higher than those of mild stenosis. The OSI value of severe stenosis is higher at distal to throat of stenosis in comparison to mild stenosis. The size of recirculation zone of severe stenosis is lager than that of mild stenosis. The abnormally high peak value of RRT of severe stenosis is concentrated and located at far away from stenosis when it is compared with mild stenosis.

References

Caro, C. G.(2009). Discovery of the role of wall shear in atherosclerosis, 2009, Arterioscler Thromb Vasc Biol, 29, 158-162.

Caro, C.G., Fitz-Gerald, J. M., & Schroter, R. C. (1971). Atheroma and arterial wall shear: observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis, Proc. R. Soc. Lond. B. Biol. Sci, 17(7), 109-159.

Fry, D. L. (1968). Acute vascular endothelial changes associated with increased blood velocity gradients, Circ. Res., 12, 165-197.

Gay, M., & Zhang, L. T. (2008). Numerical studies of blood flow in healthy, stenosed, and stented carotid arteries, Int. J. Numer. Meth. Fluids, DOI: 10.1002/fld1966.

Goswami, P., Mandal, D. K., Manna, N. K., & Chakrabarty, S. (2014). Study on the effect of steady, simple pulsatile and physiological pulsatileflows through a stenosed artery, Heat Mass Transfer, 50, 1343-1352.

He, X., & Ku, D. N. (1996). Pulsatile Flow in the Human Left Coronary Artery Bifurcation: Average Conditions, Journal of Biomechanical Engineering, 118, 74-82.

Himburg, H. A., Grzybowski, D. M., Hazel, A. L., Lamack, A, J. A., Li, X. M., & Friedman, M. H. (2004). Spatial Comparison between Wall Shear Stress Measures and Porcine Arterial Endothelial Permeability, American Journal of Physiology - Heart and Circulatory Physiology, 286, 1916-1922.

Kinght, J., Olgac, U., Saur, S. C., Poulikakos, D. W., Cattin, P. C., Kurtcuoglu, H. V. (2010). Choosing the optimal wall shear parameter for the prediction of plaque location—A patient-specific computational study in human right coronary arteries, Atherosclerosis, 211, 445-450.

Ku, D. N. (1997). Blood flow in arteries, Annu. Rev. Fluid Mech., 29, 399–434.

Ku, D. N., Giddens, D. P., Zarins, C. K., & Glagoy, S. (1985) Pulsatile flow and atherosclerosis in the human carotid bifurcation—positive correlation between plaque location and low and oscillating shear– stress, Arteriosclerosis, 5, 293–302.

Liu, B. (2013). The Wall Shear Stress of a Pulsatile Blood Flow in a Patient Specific Stenotic Right Coronary Artery, Engineering, 5, 396-399.

Liu, G.T., Wang, X. J., Ai, B. Q., & Liu, L. G. (2004) Numerical Study of Pulsating Flow Through a Tapered Artery with Stenosis, Chinese Journal of Physics , 42(4-1), 401-409.

Lee, S. W., Antiga, L., & Steinman, D. A. (2009). Correlations among indicators of disturbed flow at the normal carotid bifurcation, Journal of Biomechanical Engineering, 131, 061013 (1-7).

Malek, A. M., Alper, S. L., & Izumo, S. (1999). Hemodynamic shear stress and its role in atherosclerosis, JAMA, 282, 2035-2042.

Misra, J. C., & Shit, G. C. (2006). Blood Flow Through arteries in a Pathological State: A Theoretical study, International Journal of Engineering Science, 44, 662-671.

Ojha, M., Cobbold, R.S.C., Johnston, K.W., & Hummel, R.L. (1989) Pulsatile flow through constricted tube: an experimental investigation using photochromic tracer method, Journal of Fluid Mechanics, 203, 173–197.

Patankar, S.V. (1980) Numerical Heat Transfer, North Holland.

Peiffer, V., Sherwin, S. J., & Weinberg, P. D. (2013). Does low and oscillatory wall shear stress correlate spatially with early atherosclerosis? A systematic review, Cardiovascular Research , 99, 242–250.

Razavi, A., Shirani, E., & Sadeghi, M. R. (2011). Numerical simulation of blood pulsatile flow in a stenosed carotid artery using different rheological models, Journal of Biomechanics, 44, 2021–2030.

Ryou, H. S., Kim, S., Kim, S.W., & Cho, S. W. (2012) Construction of healthy arteries using computed tomography and virtual histology intravascular ultrasound, Journal of Biomechanics, 45, 1612–1618.

Sherwin, S. J., & Blackburn, H. M. (2005). Three-dimensional instabilities and transition of steady and pulsatile axisymmetric stenotic flows, J. Fluid Mech., 533, 297–327.

Womersley, J. R. (1955). Method for the calculation of velocity, rate of flow, and viscous drag in arteries when the pressure gradient is known, J. Physiol, 127, 553-563.

Wootton, D. M., & Ku, D. N. (1999). Fluid mechanics of vascular systems, diseases, and thrombosis, Annual Review of Biomedical Engineering, 1, 299–329.

Downloads

Published

2016-11-15

How to Cite

Goswami, P., Mandal, D. K., Manna, N. K., & Chakrabarty, S. (2016). ANALYSIS OF WALL SHEAR PARAMETERS OF PHYSIOLOGICAL PULSATILE FLOW THROUGH MILD AND SEVERE ARTERIAL STENOSIS AND CORRELATION TO ATHEROSCLEROSIS. MATTER: International Journal of Science and Technology, 2(3), 40–54. https://doi.org/10.20319/Mijst.2016.23.4054

Most read articles by the same author(s)