PROGRANULIN: IS IT A NEW ADIPOCYTOKINE AT THE CROSSROADS OF OBESITY, METABOLIC SYNDROME AND CANCER?
Keywords:Children, Progranulin, Obesity, Metabolic Syndrome, Cancer
Progranulin (PGRN) stimulates the proliferation and survival of several cancer cell types. Obesity increases the risk for metabolic as well as cardiovascular diseases, and is linked to an increased incidence and aggressiveness of various cancers. Prepubertal morbid obese (MO) children and those with metabolic syndrome (MetS)(MO+MetS)were included in our studies. World Health Organization age- and sex-dependent body mass index percentile tables were used for the classification of obesity. MetS criteria were defined. Anthropometric measurements, blood pressure values, lipid and glucose metabolism–related parameters, obesity-related adipocytokines were determined. Statistical evaluations were performed. Our studies have pointed out an increasing trend going from MO towards MO+MetS group in terms of PGRN. Elevated PGRN can contribute to tumour microenvironment, stimulate growth, invasion and metastasis of cancer cells. Children with MetS have the tendency of developing chronic diseases such as cancer in their future lives. Obesity, a major public health problem, increases the risks for many severe chronic diseases. Elevated PGRN levels may promote tumor growth, serve as a potential clinical biomarker in cancer and be associated with the increased cancer risk in children with MetS. As a new molecule, PGRN may provide a new intervention target for molecular treatment options.
Abella, V., Pino, J., Scotece, M., Conde, J., Lago, F., Gonzalez-Gay, M. A., Mera, A., Gómez, R., Mobasheri, A., & Gualillo, O. (2017). Progranulin as a biomarker and potential therapeutic agent. Drug Discovery Today, pii: S 1359-6446(17)30111-3.
Bateman, A., & Bennett, H. P. (2009). The granulin gene family: From cancer to dementia. BioEssays, 31(11), 1245–1254. https://doi.org/10.1002/bies.200900086
Beltowski, J. (2017). Role of progranulin in the regulation of vascular tone: (patho)physiological implications. Acta Physiologica, 219:706-708. https://doi.org/10.1111/apha.12799
Booth, A., Magnuson, A., Fouts, J., & Foster, M. (2015). Adipose tissue, obesity and adipokines: role in cancer promotion. Hormone Molecular Biology and Clinical Investigation, 21(1), 57-74. https://doi.org/10.1515/hmbci-2014-0037
Buraschi, S., Xu, S. Q., Stefanello, M., Moskalev, I., Morcavallo, A., Genua, M., Tanimoto, R., Birbe, R., Peiper, S. C., Gomella, L. G., Belfiore, A., Black, P. C., Iozzo, R.V., & Morrione, A. (2016). Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. Oncotarget, 7(26), 39980-39995. https://doi.org/10.18632/oncotarget.9556
Cabia, B., Andrade, S., Carreira, M. C., Casanueva, F. F., & Crujeiras, A. B. (2016). A role for novel adipose tissue-secreted factors in obesity-related carcinogenesis. Obesity Reviews, 17(4), 361-376. https://doi.org/10.1111/obr.12377
Cignarelli, A., Perrini, S., Ficarella, R., Peschechera, A., Nigro, P., & Giorgino, F. (2012). Human adipose tissue stem cells: relevance in the pathophysiology of obesity and metabolic diseases and therapeutic applications. Expert Reviews in Molecular Medicine, 14, e19. https://doi.org/10.1017/erm.2012.13
DeClercq, V., McMurray, D. N., & Chapkin, R. S. (2015). Obesity promotes colonic stem cell expansion during cancer initiation. Cancer Letters, 369(2), 336-343. https://doi.org/10.1016/j.canlet.2015.10.001
Di Francesco, S., & Tenaglia, R. L. (2017). Metabolic syndrome and aggressive prostate cancer at initial diagnosis. Hormone and Metabolic Research, 49(7), 507-509.
Divella, R., Daniele, A., Mazzocca, A., Abbate, I., Casamassima, P., Caliandro, C., Ruggeri, E., Naglieri, E., Sabba, C., & De Luca, R. (2017). ADIPOQ rs266729 G/C gene polymorphism and plasmatic adipocytokines connect metabolic syndrome to colorectal cancer. Journal of Cancer, 8(6), 1000-1008. https://doi.org/10.7150/jca.17515
Donma, M. M. (2015). Editorial. Potential mechanisms for obesity-astma link. Jacobs Journal of Obesity, 1(1), 003, 1-3.
Donma, M. M. (2016). Editorial. Milestones along the way towards the inflammatory triad of obesity, asthma and liver diseases. Southern Medical Journal of Pediatrics, 1(1), 1003-1004.
Donma, M. M., Donma, O., Michalke, B., Halbach, S., & Nischwitz, V. (2012). Vitamins, Minerals and Metabolic Pathways in Health and Diseases. Istanbul, Istanbul University Publishing House.
Donma, M. M., Karasu, E., Ozdilek B., Turgut, B., Topcu, B., Nalbantoglu, B., & Donma, O. (2015). CD4(+), CD25(+), FoxP3(+) T regulatory cell levels in obese, asthmatic, asthmatic obese, and healthy children. Inflammation, 38(4), 1473-1478. https://doi.org/10.1007/s10753-015-0122-4
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