NANO-FE AND MWCNTS BASED NON-ENZYMATIC SENSOR FOR DETERMINATION OF GLUCOSE IN SERUUM
DOI:
https://doi.org/10.20319/lijshls.2015.s11.139150Keywords:
Non-Enzyme Sensor, Glucose, Multiwall Carbon Nanotubes, Nano-Fe ParticlesAbstract
The enzyme sensors based on glucose oxidase have been widely used for the detection of blood glucose. However, the activity of enzyme can be easily affected by temperature, pH, humidity and toxic chemical. Nanostructured metal-oxides have been extensively explored to develop nonenzymatic glucose sensors. An amperometric electrode based on multiwall carbon nanotubes (MWCNTs) and Fe nanoparticles has been successfully fabricated. The electrode exhibits the linear regression equation is: I = -0.1985 + 1.7499 CG (correlation coefficient is 0.9994). Linear response range: 0.2-20.0 mM, sensitivity: 1.75 a/am, the LOD was evaluated to be 0.03 mM according to IUPAC regulations (S/N = 3). Interference tests illustrated that 0.2 me of ascorbic acid and uric acid didn't have effect on the determination of glucose. In the presence of 0.02 M chloride ion, the current signal of 0.2 mM glucose almost keeps unchanged at the sensor, revealing that this new sensor has high tolerance level to chloride ion. The sensor has been successfully applied to determine glucose in the serum samples and obtained consist results with conventional spectrometry.
References
Chen, J., Zhang, W.D., Ye, J.S. (2008). No enzymatic electrochemical glucose sensor based on MnO2/MWNTs nanocomposite. Electrochem. Commun, 10, 1268–1271.
ChenT., Li X.W., QiuC.C., Zhu W.C., Ma H.Y., Chen S.H., Meng O. (2014). Electrochemical sensing of glucose by carbon cloth-supported Co3O4/PbO2 core-shell nanorod arrays, Biosensors and Bioelectronics, 53 (15), 200–206
Chen X.L., Pan H.B., Liu H.F., Du M. (2010). No enzymatic glucose sensor based on flowershapedAu@Pd core–shell nanoparticles–ionic liquids composite film modified glassy carbon electrodes, ElectrochimicaActa56, 636–643
Cui, H.F., Ye, J.S., Zhang, W.D., Li, C.M., Luong, J.H.T., Sheu, F.S. (2007). Selective and sensitive electro-chemical detection of glucose in neutral solution using platinum-lead alloy nanoparticle/carbon nanotube nanocomposites. Anal. Chim. Acta, 594, 175–183.
Ding R.M., Liu J.P., Jiang J., Zhu J.H., Huang X.T.(2012). Mixed Ni–Cu-oxide nanowire array on conductive substrate and its application as enzyme-free glucose sensor, Anal. Methods, 4,4003-4008
Ding Y., Wang Y., Zhang L.C., Zhang H., Lei Y.(2012). Preparation, characterization and application of novel conductive NiO–CdOnanofibers with dislocation feature, J. Mater. Chem., 22, 980-986
Dong J.P.,Tian T.L., Ren L.X, Zhang Y, Xu J.Q., Cheng X.W. (2015). CuO nanoparticles incorporated in hierarchical MFI zeolite as highlyactiveelectrocatalyst for non-enzymatic glucose sensing, Colloids and Surfaces B: Biointerfaces 125, 206–212
Guo M.Q., Wang R., Xu X.H. (2011). Electro synthesis of pinecone-shaped Pt–Pub nanostructures based on the application in glucose detection, Materials Science and Engineering C 31, 1700–1705
Jiang, L.C., Zhang, W.D. (2010). A highly sensitive no enzymatic glucose sensor based on Cu Onanoparticles-modified carbon annotate electrode. Biosens. Bioelectron. 25, 1402–1407.
Kang, X.H., Mai, Z.B., Zou, X.Y., CAI, P.X., Mo, J.Y. (2007). A sensitive nonenzymatic glucose sensor in alkaline media with a copper nanocluster/multiwall carbon annotatemodified glassy carbon electrode. Anal. Biochem 363, 143–150.
Li, M., Liu, L.B., Xiong, Y.P., Liu, X.T., Nsabimana, A., Bo, X.J., Guo, L.P. (2015). Bimetallic MCo (M = Cu, Fe, Ni, and Mn) nanoparticles doped-carbon nanofibers synthesized by electrospinning for no enzymatic glucose detection. Sensors and Actuators B207, 614-622
Li,X., Hu A.Z.,Jiang J., Ding .M., Liu J.P., Huang X.T. (2011). Preparation of nickel oxide and carbon nanosheet array and its application in glucose sensing, Journal of Solid State Chemistry, 184 (10), 2738–2743,
Li, Y., Song, Y.Y., Yang, C., Xia, X.H. (2007). Hydrogen bubble dynamic template synthesis of porous gold for no enzymatic electrochemical detection of glucose. Electrochem. Commun 9, 981–988.
Liu, Y., Teng, H., Hou, H.Q., You, T.Y. (2009). Nonenzymatic glucose sensor based on renewableelectrospun Ni nanoparticle-loaded carbon nanofiber paste electrode. Biosens Bioelectron. 24, 3329–3334.
Lu, L.M., Zhang, L., Qu, F.L., Lu, H.X., Zhang, X.B., Wu, Z.S., Huan, S.Y., Wang, Q.A., Shen, G.L., Yu, R.Q. (2009). A nano-Ni based ultrasensitive no enzymatic electrochemical sensor for glucose: Enhancing sensitivity through a nanowire array strategy. Biosens. Bioelectron. 25, 218–223.
Luo, S.P., Chen Yu, Xie A.J. (2014), Nitrogen Doped Graphene Supported Ag Nanoparticles as Electrocatalysts for Oxidation of Glucose, ECS Eectrochem Lett, 3, B20-B22
Mercado, R.C., Moussy, F. (1998). In vitro and in vivo mineralization of nafion membrane used for implantable glucose sensors. Biosens. Bioelectron.,13, 133–145.
Moussy, F., Jakeway, S., Harrison, D.J., Rajotte, R.V. (1994).In vitro and in vivo performance and lifetime of perfluorinatedionomer-coated glucose sensors after high-temperature curing. Anal. Chem. 66, 3882–3888.
Nie, H., Yao, Z., Zhou, X., Yang, Z., Huang, S. (2011). No enzymatic electrochemical detection of glucose using well-distributed nickel nanoparticles on straight multi-walled carbon nanotubes. Biosens. Bioelectron 30, 28–34.
Park, S., Chung, T.D., Kim, H.C. (2003). No enzymatic glucose detection using mesoporous platinum. Anal. Chem., 75, 3046–3049.
Privets, B.J., Shin, J.H., Schoenfisch, M.H.(2008). Electrochemical sensors. Anal. Chem. 80, 4499–4517
Safavi, A., Maleki, N., Farjami, E. (2009). Fabrication of a glucose sensor based on a novel nanocomposite electrode. Biosens. Bioelectron., 24, 1655–1660.
Wang, J., homas, D.F., Chen, A. (2008). Nonenzymatic electrochemical glucose sensor based on nanoporousPtPb networks. Anal. Chem., 80, 997–1004.
Wang J., Zhang W. D. (2011). Fabrication of CuOnanoplatelets for highly sensitive enzyme-free determination of glucose, Electrochimica Acta, 56 (22), 7510–7516
Xiao F., Zhao F.Q., Mei D.P., Mo Z.R., Zeng B.Z. (2009). Nonenzymatic glucose sensor based on ultrasonic-electrodeposition of bimetallic PtM (M= Ru, Pd and Au) nanoparticles on carbon nanotubes–ionic liquid composite film, Biosens. Bioelectron., 24, 3481–3486
Yang, J., Jiang, L.C., Zhang, W.D., Gunasekaran, S. (2010). A highly sensitive non-enzymatic glucose sensor based on a simple two-step electrodeposition of cupric oxide (CuO) nanoparticles onto multi-walled carbon nanotube arrays. Talanta, 82, 25–33.
Yang, J., Zhang, W.D., Gunasekaran, S. (2010). An amperometric non-enzymatic glucose sensor by electrodepositing copper nanocubes onto vertically well-aligned multi-walled carbon nanotube arrays. Biosens. Bioelectron., 26, 279–284.
Yang, S.L., Gang Li, G. Wang, G.F., Junhong Zhao, J.H., Gao, X.H., Qu L.B. (2015). Synthesis of Mn3O4 nanoparticles/nitrogen-doped graphene hybrid composite for nonenzymatic glucose sensor. Sensors and Actuators B221, 172-178
Yuan B.Q., Xu C.Y., Liu L., Zhang Q.Q., Ji S.Q., Pi L.P., Zhang D.J.,Huo Q.S. (2013). Cu2O/NiOx/graphene oxide modified glassy carbon electrode for the enhanced electrochemical oxidation of reduced glutathione and nonenzyme glucose sensor, ElectrochimicaActa104 78– 83
Zhang J., Ma J.L., Zhang S.B., Wang W.C., Chen Z.D. (2015). A highly sensitive nonenzymatic glucose sensor based on CuO nanoparticles decorated carbon spheres, Sensors and Actuators B211, 385-391.
Zhang J., Zhu X.L., Dong H.F., Zhang X.J., Wang W.C., Chen Z.D. (2013). In situ growth cupric oxide nanoparticles on carbon nanofibers for sensitive nonenzymatic sensing of glucose, ElectrochimicaActa105, 433– 438
Zhang, W.D., Chen, J., Jiang, L.C., Yu, Y.X., Zhang, J.Q. (2010). A highly sensitive nonenzymatic glucose sensor based on NiO-modified multi-walled carbon nanotubes. Microchim. Acta, 168, 259–265.
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